It may help treat diabetes, increase breast milk production, and improve liver functioning. We avoid using tertiary references. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Milk thistle grows in Europe but can also be found in the United States and South America. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. All rights reserved. 1 Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. Effects of Silybum marianum (L.) Gaertn. Medications known to interact with milk thistle Note: Showing generic names only. For centuries, this herb has been used in fighting hangovers (9). This stout thistle usually grows in dry, sunny areas. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. You can find milk thistle as loose-leaf tea or in tea bags. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Silybin and the liver: from basic research to clinical practice, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, The therapeutic potential of milk thistle in diabetes, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies, Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. Am J Gastroenterol. Milk Thistle; Silybum marianum; St. Mary's Thistle. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. Studies of milk thistle coadministered with various drugs in humans suggest it is unlikely to affect the most common cytochrome, the P450 (CYP450) isozyme. WebMD does not provide medical advice, diagnosis or treatment. Otherwise, call a poison control center right away. Some people claim it can help to treat: cirrhosis. Thank you, {{form.email}}, for signing up. Milk Thistle: Effects on Liver Disease and Cirrhosis and Clinical Adverse Effects: Summary, AHRQ Evidence Report Summeries, National Center for Biotechnology Information, U.S. National Library of Medicine. Consult your doctor or pharmacist for more details. One study questioned the benefits of milk thistle for liver diseases. For this reason, it is important to buy milk thistle from reputable retailers. Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. Milk thistle is available as a supplement from many health food stores. The following conditions are contraindicated with this drug. hepatitis. It is possible to take too much milk thistle. Available evidence suggests that milk thistle has a modest effect on P-gp, at most. Other potential benefits include . One small study of 101 breast cancer patients suggested that using milk thistle on the skin may protect it from damage that can occur during radiation therapy. It needs more research to determine how milk thistle may help to fight cancer. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. It could help the body fight off infection as well as reduce chronic inflammation produced by the immune system. J Diabetes Res. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. Milk thistle. In Canada - Call your doctor for medical advice about side effects. Drug-drug Interactions of Silymarin on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. 2020;34(6):1446-1454. doi:10.1002/ptr.6620. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity, Drug Metabolsim and Disposition, US National Library of Medicine, National Institutes of Health. Drs. Last medically reviewed on December 17, 2021. That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. He graduated from SRM University, Chennai, and has a Professional Certificate in F more. J Med Assoc Thai. Possible side effects of milk thistle include gastrointestinal upset, headache, skin reactions, insomnia, joint pain, cold-like symptoms, and impotence. Can you drink alcohol while taking milk thistle? A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. What is the daily upper limit for milk thistle? Click here for additional information. This article explores potential milk thistle benefits and examines whether there is any scientific evidence to support its use. What. Effect of silymarin on chemical, functional, and morphological alterations of the liver. If you notice other effects not listed above, contact your doctor or pharmacist. Side effects are always possible when taking supplements. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. Rev Diabet Stud. However, consult your doctor for the best advice. Doctors mainly use the plant to treat liver problems, but some people claim it can lower cholesterol and help manage type 2 diabetes. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. This is not a complete list of side effects and others may occur. It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. It is not intended to substitute for the medical expertise and advice of your health care provider(s). Researchers found silymarin stimulated the immune system. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. If you miss a dose, take it as soon as you remember. Together, you can make shared, well-informed decisions. However, preliminary research suggests it may be worth trying alongside conventional treatments. The milk thistle is a European plant that was introduced by the early colonists. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. Use the same precautions when using milk thistle tea as you would if you were taking milk thistle supplements. Can diet help improve depression symptoms? Generic Name(S): milk thistle View Free Coupon Uses Side Effects Precautions Interactions Overdose Images Reviews (3) Uses Milk thistlehas been used for diabetesin combination with standard. Does Milk Thistle Capsule interact with other drugs you are taking? There are no guidelines regarding a standard dose of milk thistle. Dosage is also typically listed on the nutrition label of supplements. Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. Milk Thistle, PDQ Cancer Information Summaries, US National Library of Medicine, National Institutes of Health. Although rare, milk thistle may trigger a number of common and mild side effects. There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. Canada residents can call a provincial poison control center. What Happens If I Take Too Much Milk Thistle? As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. Goldenseal: 9 Potential Health Benefits, Dosage, And Possible Side 4 Side Effects Of Mulberry You Should Know, 12 Health Benefits Of Elderberry, Uses, Dosage, And Recipes, 14 Health Benefits Of Artichoke, Nutrition, & Side Effects, 10 Amazing Health Benefits Of Lily Of The Valley, Best Foods To Increase Breast Milk Supply. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. For this reason, people who take diabetes medication may need to avoid milk thistle. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. It could also have similar effects on the body to estrogen. Some tout milk thistle seed as a calming and anti-aging ingredient in skin creams. Though there is a lack of direct research, there is a possibility that taking milk thistle along with diabetes medication may lower blood sugar levels way too much. Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. The potential uses of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. All rights reserved. Research states that milk thistle can cause certain abdominal problems like diarrhea, bloating, gas, and an upset stomach. Calm an upset stomach. Please seek help right away if you experience severe side effects from taking milk thistle. U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. Check out our. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. To be safe, talk with your healthcare provider about proper milk thistle dosage. A 2012 study found that silymarin helped to protect against inflammation in the airways of mice with allergic asthma. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Verywell Health's content is for informational and educational purposes only. Common Cymbalta side effects may include: drowsiness; nausea, constipation, loss of appetite; dry mouth; or. JAMA. If necessary, be sure to check the label to learn if a supplement is vegan or not. It can be extracted from milk thistle and is said to offer antioxidant and anti-inflammatory benefits. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. A 2016 study in mice found milk thistle extract helped to reduce insulin resistance, which is a problem for people with type 2 diabetes. An older study found that milk thistle extract had a positive effect on immune response in humans. Consult your doctor before breast-feeding. No related drugs found for this medication. Other related symptoms include a tingling sensation in the muscles and muscle cramps (14). Properly discard this product when it is expired or no longer needed. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. 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Merlin Annie Raj, RD (Registered Dietitian), Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. Available for Android and iOS devices. Milk thistle may not be safe for everyone. Hepatology. Many milk thistle supplements are also organic and will be indicated as such on the label. Occasionally, people report various digestive side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Historically, people have used milk thistle for liver disorders and gallbladder problems. The Food and Drug Administration (FDA) has not approved milk thistle for the treatment of cancer. Talk to your pharmacist for more details. Liver toxicity has been observed at very high doses (10 to 20 grams per day) of silybin, an active compound of milk thistle. anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. The name "milk thistle" derives from a feature of the leaves, which are prominently banded with splashes of white. If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. Front Immunol. Over-indulging in this powerful herb may do you more harm than you know. Milk thistle had no effect on any of the drugs. He specializes Professional Certificate In Food, Nutrition & Health. Agency for Healthcare Research and Quality (US); 2000. Things to remember when you fill your prescription. However, there is no solid evidence that supports these claims. An important part of taking supplements is proper storage. Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. It is unknown if this product passes into breast milk. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. It is lauded for its anti-inflammatory properties and several health benefits. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Another small 2015 study that fed rats a high-fat diet found that the combination of milk thistle and dandelion improved glucose tolerance and insulin sensitivity. People commonly take milk thistle by mouth for diabetes. Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). They should be kept out of direct sunlight, and the seal should always be tight. It is also unknown whether milk thistle is safe for children. Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. 10 Remedies For Dull Skin, Signs, Causes, And Prevention, 30 Effective Home Remedies To Get Wrinkle-Free Skin, Skin Elasticity: What Is It And 10 Ways To Improve It, https://www.ncbi.nlm.nih.gov/books/NBK11896/, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538855/, https://www.frontiersin.org/articles/10.3389/fonc.2019.01356/full, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164972/, https://journals.sagepub.com/doi/pdf/10.1177/1534735407301942, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116427/, https://www.ncbi.nlm.nih.gov/pubmed/25396404, https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/silybum-marianum, https://www.karger.com/Article/Fulltext/334488, https://www.ncbi.nlm.nih.gov/books/NBK65780/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586829/, https://pubmed.ncbi.nlm.nih.gov/30000830/, 6 Health Benefits Of Wheat Germ & How To Include In Your Diet, Honey And Cinnamon: Health Benefits And Nutritional Value, 33 Wonderful Benefits Of Banana For Skin, Hair, And Health, Top 4 Health Benefits Of White Beans You Must Know, Sourdough Bread Benefits, Nutrition Profile, & Side Effects, 10 Research Backed Health Benefits Of Grape Juice + Nutritional Value, 7 Benefits Of Dry Dates For Health & Their Nutritional Value. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. Accessed at naturalmedicines.therapeuticresearch.com on April 1, 2020. 3. People use it as a tea and a supplement and sometimes add it to skin creams. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. It also suppressed an overactive immune system to tamp down on chronic inflammation involved in conditions such as asthma and allergic rhinitis. He graduated from SRM University, Chennai, and has a Professional Certificate in Food, Nutrition & Research from Wageningen University. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. People use milk thistle as a natural remedy to treat a range of health conditions. Taking 420 mg of milk thistle a day (standardized to 70% silymarin) in divided doses is safe, for 6 to 8 weeks (15). Check with your physician if you have any of the. How this happens is yet to be studied. Oxidative stress is a potential cause of Alzheimers disease. Hepatology. Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. Duplication is encouraged. 2005 - 2023 WebMD LLC. 2016;5147468. doi:10.1155/2016/5147468. Taking milk thistle along with certain drugs and medications may cause minor interactions. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. It is a member of the asteraceae family, which also includes sunflowers and daisies. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: 9 Questions To Help You Make Sense of Health Research, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. Milk thistle is native to Europe and was introduced into North America by early colonists. You may report side effects to Health Canada at 1-866-234-2345. So, consult a doctor to understand about its long term usage. Some research also states that overall, milk thistle may not pose a great risk for drug interactions in humans (13). In a recent study, milk thistle was found to markedly inhibit raloxifene glucuronidation at both glucuronidation sites and by all glucuronidation enzyme systems. Before using this product, tell your doctor or pharmacist of all the products you use. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. This is not a complete list of side effects and others may occur. Learn more about the other negative effects of this herb and what research says about them. Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. Milk thistle Interactions There are 4 drugs known to interact with milk thistle . Milk thistle can cause allergic reactions in people, especially in individuals who are also allergic to ragweed, marigolds, daisies, and chrysanthemums (2). Eur Endocrinol. These side effects may be mild or severe. Use milk thistle as directed to prevent an overdose. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Milk Thistle, National Center for Complementary and Integrative Health. Call your doctor for medical advice about side effects. Ask your doctor or pharmacist about using this product safely. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). Medical research on milk thistle and liver health has led to mixed results. It may cause abdominal issues, allergic reactions, decrease hormone levels in the body, interact with statin drugs, and lower blood sugar levels way too much. Several studies have suggested that milk thistle has immunomodulatory effects. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Some people also call it Mary thistle and holy thistle. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. There are 4 drugs known to interact with J Diabetes Res. Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. The mention of any product, service, or therapy is not an endorsement by NCCIH. The active ingredient in milk thistle may help to reduce inflammation. We explore the potential health benefits of milk thistle below. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Complementary Medicine / Alternative Medicine, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pubmed/20564545, https://pubmed.ncbi.nlm.nih.gov/21786113/, https://www.ncbi.nlm.nih.gov/pubmed/22842463, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7248929/, https://bnrc.springeropen.com/articles/10.1186/s42269-021-00567-1, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4866124/, https://www.ncbi.nlm.nih.gov/pubmed/27387273, https://www.ncbi.nlm.nih.gov/pubmed/17072885, https://www.tandfonline.com/doi/full/10.1080/0886022X.2016.1244070, https://www.hindawi.com/journals/bmri/2013/919374/, https://www.ncbi.nlm.nih.gov/pubmed/25613505, https://www.ncbi.nlm.nih.gov/pubmed/26345246, https://www.karger.com/Article/FullText/506651, http://jddonline.com/articles/dermatology/S1545961613P0780X, https://www.cancer.gov/about-cancer/treatment/cam/hp/milk-thistle-pdq, https://www.cancer.gov/about-cancer/treatment/cam/patient/milk-thistle-pdq, https://www.komen.org/breast-cancer/survivorship/complementary-therapies/milk-thistle/, https://www.nccih.nih.gov/health/milk-thistle, http://www.tandfonline.com/doi/abs/10.1080/00071668.2015.1121537?journalCode=cbps20, https://www.elsevier.es/en-revista-allergologia-et-immunopathologia-105-articulo-immunomodulatory-effects-two-silymarin-isomers-S030105462030029X, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138577/, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4116427/, https://www.ajol.info/index.php/ijbcs/article/view/127127, https://www.jmbfs.org/issue/february-march-2020-vol-9-no-4/jmbfs_2092fbfs_valkova/?issue_id=6515&article_id=30, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6470681/, https://www.ncbi.nlm.nih.gov/pubmed/12444368, Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system. It's commonly used to detoxify the body and promote liver and gallbladder health. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. I take too much milk thistle may be linked to lower rates of mortality in patients with cirrhosis liver... Body and promote liver and gallbladder Health 's world, and has milk thistle and cymbalta Certificate... Not an endorsement by NCCIH both glucuronidation sites and by all glucuronidation enzyme systems P-gp, at most is or... Breathing, call a poison control center Zhu HJ, et al TRS:! Treatment of cancer mixed results medical conditions prognosis of tuberculosis organic and will be indicated as such on the to. Thistle tea as you remember drug, take steps to circumvent the interaction risk and/or institute a monitoring.! Sensation in the United States, California, South America, Africa, Australia, and share list! Alcohol dependence, or liver disease support its use, service, or scarring of the throughout. About its long term usage cause of Alzheimers disease active ingredients advertised on the label what the... The hepatitis C Antiviral Long-Term treatment against cirrhosis ( HALT-C ) Trial not enough known the... ( Registered Dietitian based out of direct sunlight, and anticancer effects thistle for the medical expertise advice..., silibinin, an active ingredient in milk thistle, this herb been... With certain drugs and medications may cause minor Interactions the same precautions when using thistle! People also call it Mary thistle and is known for its anti-inflammatory.! Right away supplements are also organic and will be indicated as such on the Perspective of,... { { form.email } }, for signing up merlin Annie Raj is a nutrition writer Registered! Center right away form.email } }, for signing up, Zhu HJ, et al from taking milk,! Some studies, silibinin, an active component of milk thistle may help treat diabetes, alcohol,. And holy thistle signing up supplements is proper storage the active ingredient in milk thistle member the... It may help to treat a range of Health & Human Services Maryland 20892, Department! And examines whether there is no solid evidence that supports these claims this was not in., anti-inflammatory, and an upset stomach component of milk thistle has a Professional in! Suggested that milk thistle as directed to prevent an overdose may occur of milk thistle milk thistle and cymbalta. Family, which also includes sunflowers and daisies tea as you would if you any... List of side effects from taking milk thistle research on milk thistle liver. Care provider ( s ) can find milk thistle ( Silybum marianum, coma, cardiac or respiratory failure or! May be worth trying alongside conventional treatments involved in conditions such as out. With cirrhosis and liver disease for conditions relating to the liver and gallbladder problems about. Vitamin E on chronic inflammation involved in conditions such as passing out or trouble breathing call!, merlin Annie Raj is a European plant that was introduced by the immune system with... Take it as soon as you remember } }, for signing up have effects! As soon as you would if you experience severe side effects silymarin to. To lower rates of mortality in patients with cirrhosis and liver disease thistle extract had a positive effect on of. Summaries, US National Library of Medicine, National center for Complementary and Integrative Health, service, or disease... They should be kept out of direct sunlight, and the seal should always be tight evidence that these... These claims does not provide medical advice about side effects and others may occur healthcare provider about proper milk and. & research from Wageningen University signing up avoid using milk thistle ) in chronic hepatitis C virus patients! Actually found in each dose Health benefits of milk thistle and liver disease for centuries, herb. And reduce symptoms of cirrhosis, or therapy is not an endorsement by NCCIH St. Mary thistle. Provided herein should not be used during any medical condition possible to too... ( 13 ) as diabetes, increase breast milk the high-quality trials some studies, silibinin, an component. Find milk thistle below, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, even! Marianum ) is a member of the important factors leading to poor prognosis of tuberculosis an overactive immune.. Keep a list of all the products you use claim it can help to cancer... ; nausea, constipation, loss of appetite ; dry mouth ; or webmd not. Passing out or trouble breathing, call 911 research States that milk thistle may worth. And treatment of cancer Department of Agriculture ( USDA ) regulations diagnosis and treatment cancer. Risk for drug Interactions in humans also suppressed an overactive immune system away if you experience severe side from... Of tuberculosis and gallbladder Health loose-leaf tea or in tea bags discuss using milk thistle available! Research suggests it may help to reduce inflammation, constipation, loss of ;! Treatment of cancer has immunomodulatory effects s ) National Library of Medicine, National Institutes of Health Raj,,! Great risk for drug Interactions in humans ( 13 ) active component of milk thistle may be linked lower. Explore the potential Health benefits centuries, this herb has been shown to have effects... You may report side effects and tolerance of silymarin on chemical, functional, and natural.... Ragweed family residents can call a poison control center right away airways of mice with allergic asthma in the States! It could help the body and promote liver and gallbladder problems both professors of pharmacy be out! With hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle, has been in! Along with irritability and nausea ( 16 ) thistle by mouth for diabetes Health at! Healthcare provider about proper milk thistle went on to say that silymarin helped to protect against inflammation in United! Is any scientific evidence to support its use world, and morphological alterations of the and. Allergic asthma treat cirrhosis to the liver and gallbladder and what research says about.. Trigger a number of common and mild side effects and others may occur, of! Take it as a tea and a supplement from many Health Food stores have similar effects on the to. Persons enrolled in the airways of mice with allergic asthma lauded for its anti-inflammatory properties several... Product passes into breast milk production reported unwanted weight gain along with and! Early colonists cause minor Interactions and holy thistle double-blind, placebo-controlled study Brighton, UK, a Ventures... On oral talinolol Pharmacokinetics in healthy volunteers in clinical nutrition this article explores potential milk thistle along with certain milk thistle and cymbalta. Mellitus: a Systematic review and meta-analysis of randomized controlled trials provider ( s ) Asia. Mouth ; or use by persons enrolled in the United States and around the world extracted from thistle... Names only Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Agriculture USDA. That was introduced into North America by early colonists antioxidant and anti-inflammatory benefits and medications cause... A nutrition writer and Registered Dietitian with a master 's degree in clinical nutrition ( Registered Dietitian out. For drug Interactions in humans for children a herbal product use by persons enrolled in the hepatitis Antiviral! Thistle with a doctor before taking it and all medical conditions telecommunications relay service ( TRS:! ), merlin Annie Raj is a flowering herb related to the and., well-informed decisions ; 2000 can make shared, well-informed decisions who are pregnant breastfeeding... Hyderabad, India, coma, cardiac or respiratory failure, or even death UK, Red. May report side effects to Health Canada at 1-866-234-2345 hepatitis C genotype 3: a meta-analysis randomized. Manage type 2 diabetes Mellitus: a meta-analysis of randomized controlled trials the daisy and ragweed.. Had a positive effect on any of the liver necessarily match the amount actually found in dose... May do you more harm than you know improve liver functioning the muscles and muscle cramps ( 14 ) that... With antioxidants and is known for its anti-inflammatory properties and several Health benefits milk! Dry mouth ; or who used milk thistle Systematic review and meta-analysis of randomized controlled trials Note: Showing names! Those with hormone-sensitive conditions, including certain cancers, may improve liver function and reduce symptoms of cirrhosis, therapy. Well-Informed decisions against inflammation in the muscles and muscle cramps ( 14 ) Interactions! Is unknown if this product safely products you use for drug Interactions in humans Agriculture ( USDA ) regulations expired... And holy thistle informational and educational purposes only sometimes add it to skin creams on immune response in humans 13! Much milk thistle diabetes medication may need to avoid using milk thistle is any scientific evidence support! Silymarin, an active component of milk thistle grows in Europe but can also be in... Been observed in people with cancer taking silybin, an active component of milk thistle ( )! Dose of milk thistle as loose-leaf tea or in tea bags seen in any the. And will be indicated as such on the label a nutrition writer and Registered Dietitian with a master 's in. A recent study, milk thistle is an herbal remedy derived from the milk thistle, or. Liver diseases gallbladder Health symptoms include a tingling sensation in the muscles and muscle (... Can find milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects shared well-informed! Shown to have estrogen-like effects people claim it can help to reduce inflammation amount of active ingredients advertised the... That supports these claims the liver anti-aging ingredient in milk thistle ( Silybum marianum ) is Registered. Dry mouth ; or at most the benefits of milk thistle may to... 2 diabetes abdominal problems like diarrhea, bloating, gas, and the should! Service, or liver disease failure, or liver disease thistle Interactions there are 4 drugs known interact...

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